FISH: BCR / ABL OR PHILADELPHIA TRANSLOCATION
ITEM ID
XX001
Item Name
FISH: BCR / ABL OR PHILADELPHIA TRANSLOCATION
DOCTOR SPECIALITY
Oncologist, Hematologist
DISEASE DESCRIPTION
Leukemia
Test Status
Active
FISH: BCR / ABL OR PHILADELPHIA TRANSLOCATION
Specimen
5 mL (3 mL min.) Whole blood OR 4 mL ( 2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Method:
FISH
Report:
Sample submitted by 2nd day of the month. Report issued in 4 weeks.
Usage:
The t(9;22) is a balanced translocation between chromosomes 9 & 22 leading to fusion of bcr & c-abl genes and to the transcription of leukemia specific bcr-abl mRNAs. Philadelphia (Ph) chromosome causing the BCR/ABL fusion, is present in approximately 95% cases of Chronic myeloid leukemia (CML) and 25-30% cases of Acute lymphoblastic leukemia (ALL). Due to development of potent tyrosine kinase inhibitors & anti-sense therapies, presence of BCR/ABL translocation is a favorable prognostic marker.
Doctor Specialty:
Oncologist, Hematologist
Disease:
Leukemia
Components::
BCR - ABL t(9;22) Translocation Assay
Department:
FISH
Pre Test Information:
Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.